The development of and capacity for arousal regulation is multifaceted. A comprehensive treatment approach to establishing and supporting self-regulation extends beyond treatment aimed at sensory processing or cognitive strategies alone. Instead, therapists must employ a multiple brain and body system approach to treatment. Starting with a brief discussion on arousal and self-regulation, Sheila, Amy, and Heather will discuss the development of Powerfully You, a social emotional learning curriculum designed to foster self-regulation.